by Nootropical_USA | Sep 21, 2022 | CBD
The endocannabinoid Structure is complex, primarily consisting of receptors, enzymes, and endocannabinoids. Extensive research was conducted, starting in the ’90s regarding CBD. There are over 100 medicinal benefits. The most known and conclusive are appetite, sleep, mood, and memory. There is much to be discovered about the effects on physical and mental ailments.
What is fascinating, is the fact that our bodies already possess receptors called endocannabinoids (That are within our bodies). The cannabinoids within CBD connect with the endocannabinoids and do magical things to the body. There are two types of receptors. The other fascinating aspect of the endocannabinoid structure is that it exists in animals too. Endocannabinoid systems have been found in mammals, birds, reptiles, and fish. CBD and cannabis have been part of veterinary medicine for a long time. Ancient Greeks used cannabis to treat horses for colic, and inflammation, and to heal battle wounds. Walter E. Dixon published research in the British Medical Journal in 1899 related to cannabis and its response in cats and dogs.
Potential benefits include pain management, inflammation reduction, arthritis relief, seizure management, aiding in the loss of appetite, and cancers. Many endocannabinoid systems in animals are not being activated, because of a lack of endocannabinoids in the food we eat. Hemp is being taken out of food and there are no CBD medicinal benefits for humans or animals. Hence the reason for digesting CBD directly into the body of animals and humans daily.
A) CBD1 receptors are expressed throughout the brain, like a circuit breaker that releases inhibitory and excitatory neurotransmitters. These receptors are abundant in the nervous system, primarily localized in the central and peripheral neurons. CB1
receptors are responsible for the psychoactive effects of cannabis. The CBD1 receptor exists within the Central Nervous System (Consisting of the areas within the spinal cord and brain) and primarily controls our movement, pain, mood, appetite, and more…
Cannabinoid Receptor 1 or CB1 is associated with psychoactive, neuromodulatory, and analgesic effects due to its activation by a lipid called tetrahydrocannabinol (THC).
B) CB2 Receptors are expressed in the immune cells; including leukocytes (White blood cells), splenocytes (Splenic white blood cells), osteoblasts (Cells that secrete matrix for bone formation), osteoclasts (The bone cell that absorbs bone tissue during growth and
healing). CB2 receptors help control the release of cytokines linked to inflammation and immune function. Studies have suggested that this receptor may assist in the selection of inputs that guide complex behavior. CBD2 receptors are found within the sense organs or Peripheral Nervous System (Which consists of nerves lying outside of the central nervous system) its primary role is to connect the Central Nervous system with the body’s organs, limbs, and skin. Phytocannabinoids found in hemp largely activate CB2,
thus exerting positive, non-psychoactive effects on the human body.
by Nootropical_USA | Sep 15, 2022 | CBD
The information based on studies regarding cancer is fascinating. The American Cancer society seems to have embraced CBD. Their documentation clearly states that CBD possesses health benefits, and drugs using CBD extracts now exist. ACS cannot show the public that they are doing backflips (deep down inside) as the FDA and others keep them under scrutiny. CBD, with the appropriate dosages, could provide multiple health benefits when taking the correct oils, edibles, or water-soluble products, within their natural form.
From the American Cancer Society:
“How can marijuana affect the symptoms of cancer?
Several small studies of people who smoked marijuana found that it can be helpful in treating nausea and vomiting from cancer chemotherapy.
A few studies have found that inhaled (smoked or vaporized) marijuana can be a helpful treatment for neuropathic pain (pain caused by damaged nerves). Smoked marijuana has also helped improve food intake in HIV patients in studies. There are no studies on the effects of marijuana oil or hemp oil. Studies have long shown that people who took marijuana extracts in clinical trials tended to need less pain medicine.
More recently, scientists reported that THC and other cannabinoids, such as CBD, slow growth and/or cause death in certain types of cancer cells growing in lab dishes. Some animal studies also suggest certain cannabinoids may slow growth and reduce the spread of some forms of cancer.
There have been some early clinical trials of cannabinoids in treating cancer in humans and more studies are planned. While the studies so far have shown that cannabinoids can be safe in treating cancer, they do not show that they help control or cure the disease.
Relying on marijuana alone as treatment while avoiding or delaying conventional medical care for cancer may have serious health consequences.”
Source: The American Cancer Society
by Ira Bey | Jul 31, 2022 | CBD
CBD And Cancer
CBD inhibits cancer cells by blocking the receptors that cause cancer cell growth, suppressing the growth of cancer cells. In 2019, studies were conducted inside humans and animals (In Vivo) and outside living organisms (In Vitro). These studies on pancreatic cancer found that cannabinoids can help slow down tumor growth, diminish tumor invasion, and engender tumor cell death. Read more… 
Scientists are examining whether CBD could relieve some of the side effects caused by chemotherapy and whether CBD can slow down or prevent the growth or spread of cancer.
There have been successful breakthroughs with CBD obstructing cancer cells in mice and human cells with lung and colon cancer.
Some studies show that CBD and THC combinations could relieve pain, insomnia, anxiety, depression, and other psychological and psychological ailments. There have been success stories with people taking CBD and helping them with nausea and vomiting during chemotherapy treatments.
CBD is known to possess over 100 medicinal benefits, including hindering cancer. There have not been known side effects within these studies as there are with most synthetic drugs. Why not take CBD for disease treatment, maintenance, or prevention?
Let’s start with one, very intriguing CBD function relating to MS. Multiple Sclerosis (MS) – Is a state that can affect the brain and spinal cord, causing a variety of potential symptoms, including problems with the body, leg, and arm movements, coupled with balance, sensation, and vision. If not treated properly, MS can be detrimental to one’s health and lifestyle. There have been many conclusive studies on CBD and its ability to strengthen the myelin sheath, which is a fatty lipid that covers and protects the central nervous system. Studies have shown that it can be a preventative measure and treatment method, slowing down the progression of MS. Technically, there has not been a cure for MS to date, however, there have been numerous studies and success stories relating to CBD as a preventative and treatment for MS. Throughout this series, we will explore this and many other medicinal benefits of the Hemp, CBD, and Cannabis.
Professionals believe CBD affects your brain by attaching to specific receptors in the central nervous system. The Plant changes the way these receptors respond to stimulation. Essentially with this disease,
MS forms when the myelin sheath that protects the central nervous system starts to deteriorate and gets damaged. With MS, the body’s immune system attacks the central nervous system. Experts believe that MS could be a combination of genetics and environmental factors.
Studies have shown that CBD repairs or strengthens the myelin sheath, the fatty lipid that starts at the top of our brain’s cerebellum and extends to the bottom of our spines. Interesting studies have shown the successful combination of products containing higher levels of THC (CBD Isolate or Crude contains 0% THC, and Full/Broad Spectrum CBD can have only up to .03% THC).
THC levels beyond 3% may ease inflammation and help your brain’s immune responses, which are two common symptoms of MS. Below is an interesting case study among many; stay tuned for more information…
MS Case Study Provided by the National Library of Medicine (National Library for Biotechnology information):
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806860/#abstract-1title
The endocannabinoid system is a naturally occurring complex nerve system that helps to bring the body back to a state of homeostasis. The science behind how this works is quite fascinating. The human and animal bodies were created to connect with this Plant or vice versa, like the chicken and the egg (Which one came first). CBD Studies have shown the discovery of over 100 medicinal benefits. Endocannabinoid Receptors are the “docking stations” that naturally occur throughout the body. They perform different jobs throughout, but their goal is to keep the balance and flow of neurotransmitters, hormones, and immune cells. The most well-known are the CB1 and CB2 receptors, but as research continues, they have identified other CB- type receptors. We will touch on more details regarding this in the future. Endocannabinoid Molecules are natural chemicals produced in our body that talk to the receptors.
The main two molecules are:
- Anandamide – A partial agonist of the CB1 and CB2 receptors.
- 2-Arachidonoylglycerol (2-AG) – This is abundant in the brain at the CB1 and CB2 receptors. Anandamide plays a role in enhancing pleasure and motivation while regulating appetite, and sleep, and alleviating pain.
CB1 Receptors– Expressed throughout the brain, like a circuit breaker that releases inhibitory and excitatory neurotransmitters. These receptors are abundant in the nervous system, primarily within the central and peripheral neurons. CB1 receptors – Are responsible for the psychoactive effects of cannabis.
CB2 Receptors– Expressed in the immune cells, including leukocytes (white blood cells), splenocytes (splenic white blood cells), osteoblasts (cells that secrete matrix for bone formation), and osteoclasts (The bone cell that absorbs bone tissue during growth and healing). CB2 receptors help control the release of cytokines linked to inflammation and immune function. Studies have suggested that this receptor may assist in selecting inputs that guide complex behavior.
Research has shown that more receptors exist, but less information is available regarding the discoveries. They are called CB-type receptors. They include TRPV1, which assists with pain transmission; GPR55, assisting with energy, homeostasis, and metabolic dysregulation; GPR18, regulating physiological functions, intraocular pressure, and cell mitigation; GPR30, which reacts to estrogen with rapid signaling; and GPR119, “a fat sensor,” reducing food intake and weight gain. Endocannabinoid systems exist in mammals, birds, reptiles, and fish. CBD and cannabis have been part of veterinary medicine for a long time. Ancient Greeks used cannabis to treat horses for colic and inflammation and to heal battle wounds. Walter E. Dixon published research in the British Medical Journal in 1899 on cannabis and its response in cats and dogs. Potential benefits include pain management, inflammation reduction, arthritis relief, seizure management, aiding in the loss of appetite, and cancers. Many endocannabinoid systems within animals remain dormant in their bodies from a lack of cannabinoids in their food.
